Conclusions: Synthetic structural analogs of salinomycin, previously shown to exhibit Chemical modification and structure-activity correlation of salinomycin.

Salinomycin sodium salt(55721-31-8) Reference standards for Pharmacological research. IC50: 7.7, 13.7 and 10.4 μM for HepG2, SMMC-7721 and BEL-7402 cell line, respectively (after 24h treatment)Salinomycin (Sal) sodi

Using a structure estimation method based on molecular connectivity indices(1), the Koc of salinomycin can be estimated to be 6050(SRC). According to a classification scheme(2), this estimated Koc value suggests that salinomycin is expected to be immobile in soil. Salinomycin. Molecular Formula C 42 H 70 O 11; Average mass 750.999 Da; Monoisotopic mass 750.491821 Da; ChemSpider ID 2342058 1973-01-01 Salinomycin sodium | C42H69NaO11 | CID 23703990 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Synthetic strategies for modification of each of the directly accessible functional groups of salinomycin are presented and the resulting library of analogues was investigated to establish structure–activity relationships, both with respect to cytotoxicity and phenotype selectivity in breast cancer cells. 20‐O‐Acylated derivatives stand out by exhibiting both improved selectivity and activity.

Our data in human fibroblasts show that the expression and activation of a constitutively active MKK6 attenuate the effect of salinomycin on p38 and myofibroblast formation (Fig. 8). Sacox® consists of salinomycin sodium (active substance) at concentrations of 120 and 200 g/kg (Sacox® 120 and Sacox® 200), silica dioxide as flowability enhancer and calcium carbonate as structure-forming agent and diluent. Sacox® is intended to be incorporated into feedingstuffs directly and/or through premixtures. The properties of salinomycin is highlighted by a significant loss of activity by modifications directly interfering with either of the two primary ion coordinating motifs in salinomycin, the C11 ketone and the C1 carboxylate. Introduction Phenotypic heterogeneity within tumors has emerged as a key Structure, properties, spectra, suppliers and links for: Salinomycin sodium.

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To visualize cellular uptake and subcellular localization of salinomycin, we sought a fluorescent conjugate that was functionally equivalent to the native structure.

2 Product Results. | Match Criteria: Product Name, Property, Description.

Using a structure estimation method based on molecular connectivity indices(1), the Koc of salinomycin can be estimated to be 6050(SRC). According to a classification scheme(2), this estimated Koc value suggests that salinomycin is expected to be immobile in soil.

Properties 7 Dec 2011 Salinomycin (see Figure 2) is a carboxylic polyether ionophore Salinomycin and its salts exist in a pseudo‐cyclic structure because of the Salinomycin diastereoisomers and their benzoylated derivatives were synthesized and evaluated for both antiproliferative activity and neurotoxicity in vitro. Learn more about Salinomycin and get the best prices in the life science marketplace at Salinomycin chemical structure | CAS 53003-10-4 | AG Scientific, Inc. A series of 12 novel monosubstituted N-benzyl amides of salinomycin (SAL) was Molecular structures of three salinomycin derivatives in the solid state were For research use only. We do not sell to patients.

2 Product Results. | Match Criteria: Product Name, Property, Description. Empirical Formula (Hill Notation): C42H70O11. Molecular Weight: 751.00. CAS Number: 53003-10-4.
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Salinomycin inhibits proliferation and induces apoptosis of human Conclusions: Synthetic structural analogs of salinomycin, previously shown to exhibit The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin | ACS Chemical modification and structure-activity correlation of salinomycin. To visualize cellular uptake and subcellular localization of salinomycin, we sought a fluorescent conjugate that was functionally equivalent to the native structure. An active fluorescent salinomycin conjugate reveals rapid cellular uptake and a fluorescent conjugate that was functionally equivalent to the native structure. Conclusions: Synthetic structural analogs of salinomycin, previously shown to exhibit Chemical modification and structure-activity correlation of salinomycin.
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30 mars 2021 — molecule model and chemical formula. Organic chemical compound. Colorless gas. Ball-and-stick model, geometric structure and structural .

20‐O‐Acylated derivatives stand out by exhibiting both improved selectivity and activity. 2016-04-28 2017-02-10 Salinomycin with antibacterial and anticoccidial activities is a commercial polyether polyketide widely used in animal husbandry as a food additive. Malonyl-CoA (MCoA), methylmalonyl-CoA (MMCoA), and ethylmalonyl-CoA (EMCoA) are used as extension units in its biosynthesis 2017-02-15 Salinomycin. 2 Product Results. | Match Criteria: Product Name, Property, Description. Empirical Formula (Hill Notation): C42H70O11. Molecular Weight: 751.00.